Selective elimination of mRNAs in vivo: complementary oligodeoxynucleotides promote RNA degradation by an RNase H-like activity.

Oligodeoxynucleotides lead to translation arrest of complementary mRNAs in the wheat germ translation system by a degradation of the mRNA. In an attempt to develop an effective reverse genetic approach in vivo, we demonstrate that injection of short (15- to 30-nucleotide) oligonucleotides into Xenop...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Dash, P, Lotan, I, Knapp, M, Kandel, E R, Goelet, P
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 1987
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC299442/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2825169/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.22.7896
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