Efficient Tn10 transposition into a DNA insertion hot spot in vivo requires the 5-methyl groups of symmetrically disposed thymines within the hot-spot consensus sequence.
Transposon Tn10 inserts preferentially at particular insertion "hot spots" that share a symmetrical 6-base-pair consensus sequence: 5' GCTNAGC 3'. The protein that recognizes this sequence is not known but is likely to be the Tn10-encoded transposase protein. We present evidence that the 5-methyl gr...
محفوظ في:
| الحاوية / القاعدة: | Proc Natl Acad Sci U S A |
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| المؤلفون الرئيسيون: | , , |
| التنسيق: | Artigo |
| اللغة: | Inglês |
| منشور في: |
National Academy of Sciences
1987
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| الموضوعات: | |
| الوصول للمادة أونلاين: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC299434/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2825167/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.22.7876 |
| الوسوم: |
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