Use of a TGFβ type I receptor inhibitor in mouse skin carcinogenesis reveals a dual role for TGFβ signaling in tumor promotion and progression

Pharmacological inhibitors of the transforming growth factor β (TGFβ) type I receptor (ALK5) have shown promise in blocking growth of xenotransplanted cancer cell lines but the effect on a multistage cancer model is not known. To test this, we treated mouse skin with SB431542 (SB), a well-characteri...

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Bibliographic Details
Main Authors: Mordasky Markell, Lauren, Pérez-Lorenzo, Rolando, Masiuk, Katelyn E., Kennett, Mary J., Glick, Adam B.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2010
Subjects:
Carcinogenesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2994279/
https://ncbi.nlm.nih.gov/pubmed/20852150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgq191
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