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Inhibition of RIP2's tyrosine kinase activity limits NOD2-driven cytokine responses
Upon intracellular bacterial exposure, the Crohn's disease and sarcoidosis susceptibility protein NOD2 (nucleotide oligomerization domain protein 2) binds to the protein kinase RIP2 (receptor-interacting protein 2) to coordinate NF-κB (nuclear factor κ B)-mediated cytokine responses. While RIP2...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Cold Spring Harbor Laboratory Press
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2994040/ https://ncbi.nlm.nih.gov/pubmed/21123652 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1964410 |
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