Inhibition of RIP2's tyrosine kinase activity limits NOD2-driven cytokine responses

Upon intracellular bacterial exposure, the Crohn's disease and sarcoidosis susceptibility protein NOD2 (nucleotide oligomerization domain protein 2) binds to the protein kinase RIP2 (receptor-interacting protein 2) to coordinate NF-κB (nuclear factor κ B)-mediated cytokine responses. While RIP2...

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Bibliographic Details
Main Authors: Tigno-Aranjuez, Justine T., Asara, John M., Abbott, Derek W.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2010
Subjects:
Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2994040/
https://ncbi.nlm.nih.gov/pubmed/21123652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1964410
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