High-grade, chemotherapy-resistant ovarian carcinomas overexpress epithelial cell adhesion molecule (EpCAM) and are highly sensitive to immunotherapy with MT201, a fully human monoclonal anti-EpCAM antibody

BACKGROUND: We evaluated the expression of epithelial-cell-adhesion-molecule (EpCAM) and the potential of MT201 (adecatumumab), a human-monoclonal-antibody targeting EpCAM against chemotherapy resistant ovarian disease. METHODS: EpCAM expression was evaluated by real-time-PCR and flow cytometry. Sen...

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Autores principales: Richter, Christine E., Cocco, Emiliano, Bellone, Stefania, Silasi, Dan-Arin, Rüttinger, Dominik, Azodi, Masoud, Schwartz, Peter E., Rutherford, Thomas J., Pecorelli, Sergio, Santin, Alessandro D.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993821/
https://ncbi.nlm.nih.gov/pubmed/20870202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajog.2010.07.041
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