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Dysfunction of Heterotrimeric Kinesin-2 in Rod Photoreceptor Cells and the Role of Opsin Mislocalization in Rapid Cell Death

Due to extensive elaboration of the photoreceptor cilium to form the outer segment, axonemal transport (IFT) in photoreceptors is extraordinarily busy, and retinal degeneration is a component of many ciliopathies. Functional loss of heterotrimeric kinesin-2, a major anterograde IFT motor, causes mis...

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Autori principali: Lopes, Vanda S., Jimeno, David, Khanobdee, Kornnika, Song, Xiaodan, Chen, Bryan, Nusinowitz, Steven, Williams, David S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Cell Biology 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993738/
https://ncbi.nlm.nih.gov/pubmed/20926680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E10-08-0715
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