Human NK cells of mice with reconstituted human immune system components require preactivation to acquire functional competence

To investigate human natural killer (NK)–cell reactivity in vivo we have reconstituted human immune system components by transplantation of human hematopoietic progenitor cells into NOD-scid IL2Rγ(null) mice. We demonstrate here that this model allows the development of all NK-cell subsets that are...

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Hauptverfasser: Strowig, Till, Chijioke, Obinna, Carrega, Paolo, Arrey, Frida, Meixlsperger, Sonja, Rämer, Patrick C., Ferlazzo, Guido, Münz, Christian
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2010
Schlagworte:
Immunobiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993621/
https://ncbi.nlm.nih.gov/pubmed/20671122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-02-270678
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