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The RB tumor suppressor: a gatekeeper to hormone independence in prostate cancer?
The retinoblastoma tumor suppressor gene (RB1; encoding RB) is often cited as a gatekeeper, whose inactivation — direct or indirect — is a rate-limiting step for tumor initiation. However, in this issue of the JCI, Sharma et al. show that RB1 loss is a late event in human prostate cancer that is coi...
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| Hlavní autor: | |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Clinical Investigation
2010
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2993607/ https://ncbi.nlm.nih.gov/pubmed/21099103 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI45406 |
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