Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice

During the classic “fight-or-flight” stress response, sympathetic nervous system activation leads to catecholamine release, which increases heart rate and contractility, resulting in enhanced cardiac output. Catecholamines bind to β-adrenergic receptors, causing cAMP generation and activation of PKA...

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Главные авторы: Shan, Jian, Kushnir, Alexander, Betzenhauser, Matthew J., Reiken, Steven, Li, Jingdong, Lehnart, Stephan E., Lindegger, Nicolas, Mongillo, Marco, Mohler, Peter J., Marks, Andrew R.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2010
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993575/
https://ncbi.nlm.nih.gov/pubmed/21099118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32726
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