The Novel Pyrrolidine Nor-Lobelane Analog UKCP-110 [cis-2,5-di-(2-phenethyl)-pyrrolidine hydrochloride] Inhibits VMAT2 Function, Methamphetamine-Evoked Dopamine Release, and Methamphetamine Self-Administration in Rats

Both lobeline and lobelane attenuate methamphetamine self-administration in rats by decreasing methamphetamine-induced dopamine release via interaction with vesicular monoamine transporter-2 (VMAT2). A novel derivative of nor-lobelane, cis-2,5-di-(2-phenethyl)-pyrrolidine hydrochloride (UKCP-110), a...

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Detalhes bibliográficos
Main Authors: Beckmann, Joshua S., Siripurapu, Kiran B., Nickell, Justin R., Horton, David B., Denehy, Emily D., Vartak, Ashish, Crooks, Peter A., Dwoskin, Linda P., Bardo, Michael T.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2010
Assuntos:
Neuropharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993560/
https://ncbi.nlm.nih.gov/pubmed/20805303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.172742
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