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Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells

Despite their low frequency, plasmacytoid dendritic cells (pDCs) produce most of the type I IFN that is detectable in the blood following viral infection. The endosomal Toll-like receptors (TLRs) TLR7 and TLR9 are required for pDCs, as well as other cell types, to sense viral nucleic acids, but the...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Blasius, Amanda L., Arnold, Carrie N., Georgel, Philippe, Rutschmann, Sophie, Xia, Yu, Lin, Pei, Ross, Charles, Li, Xiaohong, Smart, Nora G., Beutler, Bruce
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993408/
https://ncbi.nlm.nih.gov/pubmed/21045126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1014051107
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