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Formation of μ-/κ-opioid receptor heterodimer is sex-dependent and mediates female-specific opioid analgesia
Sexually dimorphic nociception and opioid antinociception is very pervasive but poorly understood. We had demonstrated that spinal morphine antinociception in females, but not males, requires the concomitant activation of spinal μ- and κ-opioid receptors (MOR and KOR, respectively). This finding sug...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2993367/ https://ncbi.nlm.nih.gov/pubmed/21041644 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1009923107 |
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