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Formation of μ-/κ-opioid receptor heterodimer is sex-dependent and mediates female-specific opioid analgesia
Sexually dimorphic nociception and opioid antinociception is very pervasive but poorly understood. We had demonstrated that spinal morphine antinociception in females, but not males, requires the concomitant activation of spinal μ- and κ-opioid receptors (MOR and KOR, respectively). This finding sug...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2993367/ https://ncbi.nlm.nih.gov/pubmed/21041644 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1009923107 |
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