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A biochemical mechanism for the oncogenic potential of the p110β catalytic subunit of phosphoinositide 3-kinase
Class I PI3-kinases signal downstream of receptor tyrosine kinases and G protein-coupled receptors and have been implicated in tumorigenesis. Although the oncogenic potential of the PI3-kinase subunit p110α requires its mutational activation, other p110 isoforms can induce transformation when overex...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2993364/ https://ncbi.nlm.nih.gov/pubmed/21030680 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1008739107 |
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