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Experimental library screening demonstrates the successful application of computational protein design to large structural ensembles

The stability, activity, and solubility of a protein sequence are determined by a delicate balance of molecular interactions in a variety of conformational states. Even so, most computational protein design methods model sequences in the context of a single native conformation. Simulations that mode...

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Detalhes bibliográficos
Main Authors: Allen, Benjamin D., Nisthal, Alex, Mayo, Stephen L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993350/
https://ncbi.nlm.nih.gov/pubmed/21045132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1012985107
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