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Germ-line elimination of electric charge on pre–T-cell receptor (TCR) impairs autonomous signaling for β-selection and TCR repertoire formation

The pre–T-cell receptor (TCR) is crucial for the early T-cell development, but the ligand for pre-TCR remains unidentified. We recently proposed a model that pre-TCR complexes oligomerize spontaneously through interactions of the pre-TCRα chain. To investigate the mechanism underlying this ligand-in...

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Autors principals: Ishikawa, Eri, Miyake, Yasunobu, Hara, Hiromitsu, Saito, Takashi, Yamasaki, Sho
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993337/
https://ncbi.nlm.nih.gov/pubmed/21030681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1011228107
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