Plakoglobin Rescues Adhesive Defects Induced by Ectodomain Truncation of the Desmosomal Cadherin Desmoglein 1 : Implications for Exfoliative Toxin-Mediated Skin Blistering

Desmoglein 1 (Dsg1) is a desmosomal cadherin that is essential to epidermal integrity. In the blistering diseases bullous impetigo and staphylococcal scalded-skin syndrome, pathogenesis depends on cleavage of Dsg1 by a bacterial protease, exfoliative toxin A, which removes residues 1 to 381 of the D...

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Main Authors: Simpson, Cory L., Kojima, Shin-ichiro, Cooper-Whitehair, Victoria, Getsios, Spiro, Green, Kathleen J.
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993287/
https://ncbi.nlm.nih.gov/pubmed/21075858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.100397
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