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Inhibition of hydroxymethylglutaryl-coenzyme A synthase by L-659,699.

A beta-lactone isolated from Fusarium sp. has been shown to be a potent specific inhibitor of the enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase [(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating), EC, 4.1.3.5] from rat liver. The structure of this beta-lacto...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Greenspan, M D, Yudkovitz, J B, Lo, C Y, Chen, J S, Alberts, A W, Hunt, V M, Chang, M N, Yang, S S, Thompson, K L, Chiang, Y C
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 1987
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC299321/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2890166/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.21.7488
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