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Total Synthesis of Bryostatin 16 using a Pd-Catalyzed Diyne-Coupling as Macrocyclization Method and Synthesis of C20-epi-Bryostatin 7 as a Potent Anticancer Agent

Asymmetric total synthesis of bryostatin 16 was achieved in 26 steps in the longest linear sequence/39 total steps from aldehyde 10. A Pd-catalyzed alkyne-alkyne coupling was employed for the first-time as a macrocyclization method in a natural product synthesis. A route to convert bryostatin 16 to...

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Bibliografiske detaljer
Main Authors: Trost, Barry M., Dong, Guangbin
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993185/
https://ncbi.nlm.nih.gov/pubmed/21043491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja105129p
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