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Enantioselective ProPhenol-Catalyzed Addition of 1,3-Diynes to Aldehydes to Generate Synthetically Versatile Building Blocks and Diyne Natural Products

A highly enantioselective method for the catalytic addition of terminal 1,3-diynes to aldehydes was developed using our dinuclear zinc ProPhenol (1) system. Furthermore, triphenylphosphine oxide was found to interact synergistically with the catalyst to substantially enhance the chiral recognition....

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Main Authors: Trost, Barry M., Chan, Vincent S., Yamamoto, Daisuke
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2864593/
https://ncbi.nlm.nih.gov/pubmed/20307084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja910656b
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