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Controlling Regioselectivity in the Enantioselective N-Alkylation of Indole Analogs Catalyzed by Dinuclear Zinc-ProPhenol

The enantioselective N-alkylation of indole and its derivatives with aldimines is efficiently catalyzed by a zinc-ProPhenol dinuclear complex under mild conditions to afford N-alkylated indole derivatives in good yield (up to 86%) and excellent enantiomeric ratio (up to 99.5: 0.5 e.r.). This protoco...

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Bibliografiset tiedot
Julkaisussa:Angew Chem Int Ed Engl
Päätekijät: Trost, Barry M., Gnanamani, Elumalai, Hung, Chao-I (Joey)
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2017
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5706662/
https://ncbi.nlm.nih.gov/pubmed/28654735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201705315
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