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Mechanism of hypoxia-inducible factor 1α-mediated Mcl1 regulation in Helicobacter pylori-infected human gastric epithelium

Hypoxia-inducible factor 1 (HIF1) consists of a hypoxia-inducible α subunit and a constitutively expressed β subunit. Reactive oxygen species (ROS) induced by Helicobacter pylori stabilize HIF1α in the human gastric epithelium in normoxia. HIF1α plays crucial role in carcinogenesis and has been asso...

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Détails bibliographiques
Auteurs principaux: Bhattacharyya, Asima, Chattopadhyay, Ranajoy, Hall, Emily H., Mebrahtu, Semret T., Ernst, Peter B., Crowe, Sheila E.
Format: Artigo
Langue:Inglês
Publié: American Physiological Society 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993173/
https://ncbi.nlm.nih.gov/pubmed/20829524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00372.2010
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