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Convenient Synthesis of a Propargylated Cyclic (3′-5′) Diguanylic Acid and its “Click” Conjugation to a Biotinylated Azide
The ribonucleoside building block, N(2)-isobutyryl-2′-O-propargyl-3′-O-levulinyl guanosine (Scheme 1), was prepared from commercial N(2)-isobutyryl-5′-O-(4,4′-dimethoxytrityl)-2′-O-propargyl guanosine in a yield of 91%. The propargylated guanylyl(3′-5′)guanosine phosphotriester shown in Scheme 2 was...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2993019/ https://ncbi.nlm.nih.gov/pubmed/20942415 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc1003857 |
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