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A General Scheme for Synthesis of Substrate-based Polyketide Labels for Acyl Carrier Proteins
A general strategy to enzymatically label acyl carrier proteins (ACPs) of polyketide synthases has been developed. Incorporation of a chloromethyl ketone or vinyl ketone moiety into polyketide chain elongation intermediate mimics allows for the synthesis of CoA adducts. These CoA adducts undergo enz...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2992964/ https://ncbi.nlm.nih.gov/pubmed/20801036 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.05.089 |
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