A conserved motif flags Acyl Carrier Proteins for β-branching in polyketide synthesis

Type I PKSs often utilise programmed β-branching, via enzymes of an “HMG-CoA synthase (HCS) cassette”, to incorporate various side chains at the second carbon from the terminal carboxylic acid of growing polyketide backbones. We identified a strong sequence motif in Acyl Carrier Proteins (ACPs) wher...

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Publicado no:Nat Chem Biol
Main Authors: Haines, Anthony S, Dong, Xu, Song, Zhongshu, Farmer, Rohit, Williams, Christopher, Hothersall, Joanne, Płoskoń, Eliza, Wattana-amorn, Pakorn, Stephens, Elton R., Yamada, Erika, Gurney, Rachel, Takebayashi, Yuiko, Masschelein, Joleen, Cox, Russell J., Lavigne, Rob, Willis, Christine L., Simpson, Thomas J., Crosby, John, Winn, Peter J., Thomas, Christopher M., Crump, Matthew P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4658705/
https://ncbi.nlm.nih.gov/pubmed/24056399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1342
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