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Molecular Assembly of an Aptamer-Drug Conjugate for Targeted Drug Delivery to Tumor Cells

The conjugation of antitumor drugs to targeting reagents such as antibodies is a promising method that can increase the efficacy of chemotherapy and reduce their overall toxicity. In this paper, we covalently link an antitumor agent doxorubicin (Dox) to the DNA aptamer sgc8c, which was selected by t...

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Bibliografische gegevens
Hoofdauteurs: Huang, Yu-Fen, Shangguan, Dihua, Liu, Haipeng, Phillips, Joseph A., Zhang, Xiaoling, Chen, Yan, Tan, Weihong
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2009
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992821/
https://ncbi.nlm.nih.gov/pubmed/19253922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.200800805
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