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Molecular Assembly of an Aptamer-Drug Conjugate for Targeted Drug Delivery to Tumor Cells
The conjugation of antitumor drugs to targeting reagents such as antibodies is a promising method that can increase the efficacy of chemotherapy and reduce their overall toxicity. In this paper, we covalently link an antitumor agent doxorubicin (Dox) to the DNA aptamer sgc8c, which was selected by t...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2992821/ https://ncbi.nlm.nih.gov/pubmed/19253922 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.200800805 |
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