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Candesartan Attenuates Diabetic Retinal Vascular Pathology by Restoring Glyoxalase-I Function

OBJECTIVE: Advanced glycation end products (AGEs) and the renin-angiotensin system (RAS) are both implicated in the development of diabetic retinopathy. How these pathways interact to promote retinal vasculopathy is not fully understood. Glyoxalase-I (GLO-I) is an enzyme critical for the detoxificat...

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Detalhes bibliográficos
Main Authors: Miller, Antonia G., Tan, Genevieve, Binger, Katrina J., Pickering, Raelene J., Thomas, Merlin C., Nagaraj, Ram H., Cooper, Mark E., Wilkinson-Berka, Jennifer L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992784/
https://ncbi.nlm.nih.gov/pubmed/20852029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-0552
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