Accumulation of True Single Strand Breaks and AP sites in Base Excision Repair Deficient Cells

Single strand breaks (SSBs) are one of the most frequent DNA lesions caused by endogenous and exogenous agents. The most utilized alkaline-based assays for SSB detection frequently give false positive results due to the presence of alkali-labile sites that are converted to SSBs. Methoxyamine, an aci...

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Huvudupphovsmän: Luke, April M., Chastain, Paul D., Pachkowski, Brian F., Afonin, Valeriy, Takeda, Shunichi, Kaufman, David G., Swenberg, James A., Nakamura, Jun
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992575/
https://ncbi.nlm.nih.gov/pubmed/20851134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrfmmm.2010.08.008
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