Cells deficient in PARP1 show an accelerated accumulation of DNA single strand breaks, but not AP sites, over the PARP1-proficient cells exposed to MMS

Poly(ADP-ribose) polymerase-1 (PARP-1) is a base excision repair (BER) protein that binds to DNA single strand breaks (SSBs) and subsequently synthesizes and transfers poly(ADP-ribose) polymers to various nuclear proteins. Numerous biochemical studies have implicated PARP-1 as a modulator of BER; ho...

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Main Authors: Pachkowski, Brian F., Tano, Keizo, Afonin, Valeriy, Elder, Rhoderick H., Takeda, Shunichi, Watanabe, Masami, Swenberg, James A., Nakamura, Jun
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2784157/
https://ncbi.nlm.nih.gov/pubmed/19778542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrfmmm.2009.09.006
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