Structural Basis of Detection and Signaling of DNA Single-Strand Breaks by Human PARP-1

Poly(ADP-ribose)polymerase 1 (PARP-1) is a key eukaryotic stress sensor that responds in seconds to DNA single-strand breaks (SSBs), the most frequent genomic damage. A burst of poly(ADP-ribose) synthesis initiates DNA damage response, whereas PARP-1 inhibition kills BRCA-deficient tumor cells selec...

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Publicado en:Mol Cell
Main Authors: Eustermann, Sebastian, Wu, Wing-Fung, Langelier, Marie-France, Yang, Ji-Chun, Easton, Laura E., Riccio, Amanda A., Pascal, John M., Neuhaus, David
Formato: Artigo
Idioma:Inglês
Publicado: Cell Press 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4678113/
https://ncbi.nlm.nih.gov/pubmed/26626479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.10.032
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