Quantitation of intracellular NAD(P)H can monitor an imbalance of DNA single strand break repair in base excision repair deficient cells in real time

DNA single strand breaks (SSBs) are one of the most frequent DNA lesions in genomic DNA generated either by oxidative stress or during the base excision repair pathways. Here we established a new real-time assay to assess an imbalance of DNA SSB repair by indirectly measuring PARP-1 activation throu...

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Detalhes bibliográficos
Main Authors: Nakamura, Jun, Asakura, Shoji, Hester, Susan D., de Murcia, Gilbert, Caldecott, Keith W., Swenberg, James A.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2003
Assuntos:
NAR Methods Online
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC212824/
https://ncbi.nlm.nih.gov/pubmed/12930978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gng105
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