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The Rate at Which Asexual Populations Cross Fitness Valleys

Complex traits often involve interactions between different genetic loci. This can lead to sign epistasis, whereby a set of mutations are individually deleterious or neutral but in combination confer a fitness benefit. In order to acquire the beneficial genotype, an asexual population must cross a f...

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Bibliographic Details
Main Authors: Weissman, Daniel B., Desai, Michael M., Fisher, Daniel S., Feldman, Marcus W.
Format: Artigo
Language:Inglês
Published: 2009
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992471/
https://ncbi.nlm.nih.gov/pubmed/19285994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tpb.2009.02.006
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