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Blocking O-Linked GlcNAc Cycling in Drosophila Insulin-producing Cells Perturbs Glucose-Insulin Homeostasis
A dynamic cycle of O-linked GlcNAc (O-GlcNAc) addition and removal is catalyzed by O-GlcNAc transferase and O-GlcNAcase, respectively, in a process that serves as the final step in a nutrient-driven “hexosamine-signaling pathway.” Evidence points to a role for O-GlcNAc cycling in diabetes and insuli...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2992301/ https://ncbi.nlm.nih.gov/pubmed/20926386 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.155192 |
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