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Identification of Interacting Hot Spots in the β3 Integrin Stalk Using Comprehensive Interface Design
Protein-protein interfaces are usually large and complementary surfaces, but specific side chains, representing energetic “hot spots,” often contribute disproportionately to binding free energy. We used a computational method, comprehensive interface design, to identify hot spots in the interface be...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2992298/ https://ncbi.nlm.nih.gov/pubmed/20929856 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.170670 |
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