The ATM Cofactor ATMIN Protects against Oxidative Stress and Accumulation of DNA Damage in the Aging Brain

Progressive accumulation of DNA damage is causally involved in cellular senescence and organismal aging. The DNA damage kinase ATM plays a central role in maintaining genomic stability. ATM mutations cause the genetic disorder ataxia telangiectasia, which is primarily characterized by progressive ne...

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Hlavní autoři: Kanu, Nnennaya, Penicud, Kay, Hristova, Mariya, Wong, Barnaby, Irvine, Elaine, Plattner, Florian, Raivich, Gennadij, Behrens, Axel
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992286/
https://ncbi.nlm.nih.gov/pubmed/20889973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.145896
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