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Activation by phosphorylation and purification of human c-Jun N-terminal Kinase (JNK) isoforms in milligram amounts

c-Jun N-terminal kinases (JNKs) are part of the mitogen activated protein kinase (MAPK) signaling cascade. They are activated through dual phosphorylation of two residues in the activation loop, a threonine and a tyrosine, by MAP2 kinases (MKK4 and 7) in response to various extracellular stresses su...

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Detalhes bibliográficos
Main Authors: Thévenin, Anastasia F., Zony, Chati L., Bahnson, Brian J., Colman, Roberta F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2991412/
https://ncbi.nlm.nih.gov/pubmed/20709173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pep.2010.08.002
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