cJun N-terminal kinase (JNK) phosphorylation of serine 36 is critical for p66Shc activation

p66Shc-dependent ROS production contributes to many pathologies including ischemia/reperfusion injury (IRI) during solid organ transplantation. Inhibiting p66Shc activation may provide a novel therapeutic approach to prevent damage, which is poorly managed by antioxidants in vivo. Previous work sugg...

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Bibliografische gegevens
Gepubliceerd in:Sci Rep
Hoofdauteurs: Khalid, Sana, Drasche, Astrid, Thurner, Marco, Hermann, Martin, Ashraf, Muhammad Imtiaz, Fresser, Friedrich, Baier, Gottfried, Kremser, Leopold, Lindner, Herbert, Troppmair, Jakob
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4751440/
https://ncbi.nlm.nih.gov/pubmed/26868434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20930
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