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Simvastatin Inhibits Goblet Cell Hyperplasia and Lung Arginase in a Mouse Model of Allergic Asthma: A Novel Treatment for Airway Remodeling?

Airway remodeling in asthma contributes to airway hyperreactivity, loss of lung function, and persistent symptoms. Current therapies do not adequately treat the structural airway changes associated with asthma. The statins are cholesterol-lowering drugs that inhibit the enzyme 3-hydroxy-3-methyl-glu...

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Autori principali: Zeki, Amir A., Bratt, Jennifer M., Rabowsky, Michelle, Last, Jerold A., Kenyon, Nicholas J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2990975/
https://ncbi.nlm.nih.gov/pubmed/21078495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.trsl.2010.09.003
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