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Simvastatin Inhibits Goblet Cell Hyperplasia and Lung Arginase in a Mouse Model of Allergic Asthma: A Novel Treatment for Airway Remodeling?

Airway remodeling in asthma contributes to airway hyperreactivity, loss of lung function, and persistent symptoms. Current therapies do not adequately treat the structural airway changes associated with asthma. The statins are cholesterol-lowering drugs that inhibit the enzyme 3-hydroxy-3-methyl-glu...

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Détails bibliographiques
Auteurs principaux: Zeki, Amir A., Bratt, Jennifer M., Rabowsky, Michelle, Last, Jerold A., Kenyon, Nicholas J.
Format: Artigo
Langue:Inglês
Publié: 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2990975/
https://ncbi.nlm.nih.gov/pubmed/21078495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.trsl.2010.09.003
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