PARP1 Gene Knock-Out Increases Resistance to Retinal Degeneration without Affecting Retinal Function

Retinitis pigmentosa (RP) is a group of inherited neurodegenerative diseases affecting photoreceptors and causing blindness in humans. Previously, excessive activation of enzymes belonging to the poly-ADP-ribose polymerase (PARP) group was shown to be involved in photoreceptor degeneration in the hu...

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Bibliographic Details
Main Authors: Sahaboglu, Ayse, Tanimoto, Naoyuki, Kaur, Jasvir, Sancho-Pelluz, Javier, Huber, Gesine, Fahl, Edda, Arango-Gonzalez, Blanca, Zrenner, Eberhart, Ekström, Per, Löwenheim, Hubert, Seeliger, Mathias, Paquet-Durand, François
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2990765/
https://ncbi.nlm.nih.gov/pubmed/21124852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015495
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