A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents

BACKGROUND AND PURPOSE: Cannabinoid CB(1) receptor antagonists reduce food intake and body weight, but clinical use in humans is limited by effects on the CNS. We have evaluated a novel cannabinoid antagonist (AM6545) designed to have limited CNS penetration, to see if it would inhibit food intake i...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Cluny, NL, Vemuri, VK, Chambers, AP, Limebeer, CL, Bedard, H, Wood, JT, Lutz, B, Zimmer, A, Parker, LA, Makriyannis, A, Sharkey, KA
التنسيق: Artigo
اللغة:Inglês
منشور في: Blackwell Publishing Ltd 2010
الموضوعات:
Research Papers
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC2990160/
https://ncbi.nlm.nih.gov/pubmed/20880401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.00908.x
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