Inverse agonism of cannabinoid CB(1) receptors potentiates LiCl-induced nausea in the conditioned gaping model in rats

BACKGROUND AND PURPOSE: Cannabinoid CB(1) receptor antagonists/inverse agonists, potentiate toxin-induced nausea and vomiting in animal models. Here, we sought to determine if this potentiated nausea was mediated by inverse agonism or neutral antagonism of the CB(1) receptor, and if the potentiated...

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Detalhes bibliográficos
Main Authors: Limebeer, CL, Vemuri, VK, Bedard, H, Lang, ST, Ossenkopp, KP, Makriyannis, A, Parker, LA
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2010
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2989586/
https://ncbi.nlm.nih.gov/pubmed/20735419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.00885.x
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