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Primate testing of TGN1412: right target, wrong cell

The failure of toxicity studies in non-human primates to predict the cytokine release syndrome during a first-in-man study of the CD28-specific monoclonal antibody TGN1412 has remained unexplained so far. In this issue of the BJP, work from the NIBSC first identifies the effector memory subset of hu...

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Autors principals: Pallardy, M, Hünig, T
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2010
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2990150/
https://ncbi.nlm.nih.gov/pubmed/20880391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.00925.x
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