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Long-lasting target binding and rebinding as mechanisms to prolong in vivo drug action
An increasing number of examples in the literature suggest that the in vivo duration of drug action not only depends on macroscopic pharmacokinetic properties like plasma half-life and the time needed to equilibrate between the plasma and the effect compartments, but is also influenced by long-lasti...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Publishing Ltd
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2990149/ https://ncbi.nlm.nih.gov/pubmed/20880390 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.00936.x |
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