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Liver Steatosis and Increased ChREBP Expression in Mice Carrying a Liver Specific SIRT1 Null Mutation under a Normal Feeding Condition

SIRT1, a homolog of yeast Sir2, is a type III NAD(+) dependent histone and protein deacetylase. Previous studies of mice carrying liver specific deletion of exon 4 of the Sirt1 gene revealed opposite responses of mutant mice to a high-fat diet in terms of fatty liver formation, which obscures the fu...

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Detalhes bibliográficos
Main Authors: Wang, Rui-Hong, Li, Cuiling, Deng, Chu-Xia
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2990071/
https://ncbi.nlm.nih.gov/pubmed/21103071
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