Eighteen Insulin-like Growth Factor (IGF) pathway genes, circulating levels of IGF-1 and its binding protein (IGFBP-3), and risk of prostate and breast cancer

BACKGROUND: Circulating levels of insulin-like growth factor I (IGF-1) and its main binding protein, IGF binding protein 3 (IGFBP-3), have been associated with risk of several types of cancer. Heritable factors explain up to 60% of the variation in IGF-1 and IGFBP-3 in studies of adult twins. METHOD...

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Hauptverfasser: Gu, Fangyi, Schumacher, Fredrick R., Canzian, Federico, Allen, Naomi E., Albanes, Demetrius, Berg, Christine D, Berndt, Sonja I., Boeing, Heiner, Bueno-de-Mesquita, H. Bas, Buring, Julie E., Chabbert-Buffet, Nathalie, Chanock, Stephen J., Clavel-Chapelon, Françoise, Dumeaux, Vanessa, Gaziano, J. Michael, Giovannucci, Edward L., Haiman, Christopher A., Hankinson, Susan E., Hayes, Richard B., Henderson, Brian E., Hunter, David J., Hoover, Robert N., Johansson, Mattias, Key, Timothy J., Khaw, Kay-Tee, Kolonel, Laurence N., Lagiou, Pagona, Lee, I-Min, LeMarchand, Loic, Lund, Eiliv, Ma, Jing, Onland-Moret, N. Charlotte, Overvad, Kim, Rodriguez, Laudina, Sacerdote, Carlotta, Sánchez, Maria-José, Stampfer, Meir J., Stattin, Pär, Stram, Daniel O., Thomas, Gilles, Thun, Michael J., Tjønneland, Anne, Trichopoulos, Dimitrios, Tumino, Rosario, Virtamo, Jarmo, Weinstein, Stephanie J., Willett, Walter C., Yeager, Meredith, Zhang, Shumin M., Kaaks, Rudolf, Riboli, Elio, Ziegler, Regina G., Kraft, Peter
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2989404/
https://ncbi.nlm.nih.gov/pubmed/20810604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1055-9965.EPI-10-0507
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