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Age-dependent changes in TDP-43 levels in a mouse model of Alzheimer disease are linked to Aβ oligomers accumulation

BACKGROUND: Transactive response DNA-binding protein 43 (TDP-43) is the pathological protein found in frontotemporal lobar degeneration with ubiquitin positive inclusions and in amyotrophic lateral sclerosis. In diseased tissue, TDP-43 translocates from its physiological nuclear location into the cy...

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Detalhes bibliográficos
Main Authors: Caccamo, Antonella, Magrí, Andrea, Oddo, Salvatore
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2989316/
https://ncbi.nlm.nih.gov/pubmed/21070634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-5-51
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