Critical role for hyperpolarization-activated cyclic nucleotide-gated channel 2 in the AIF-mediated apoptosis

Cellular calcium uptake is a controlled physiological process mediated by multiple ion channels. The exposure of cells to either one of the protein kinase C (PKC) inhibitors, staurosporine (STS) or PKC412, can trigger Ca(2+) influx leading to cell death. The precise molecular mechanisms regulating t...

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Detalhes bibliográficos
Main Authors: Norberg, Erik, Karlsson, Marie, Korenovska, Olga, Szydlowski, Susanne, Silberberg, Gilad, Uhlén, Per, Orrenius, Sten, Zhivotovsky, Boris
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2989107/
https://ncbi.nlm.nih.gov/pubmed/21037554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.253
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