A phase I evaluation of the combination of vinflunine and erlotinib in patients with refractory solid tumors

PURPOSE: Epidermal growth factor receptor (EGFR) inhibition may overcome chemotherapy resistance by inhibiting important anti-apoptotic signals that are constitutively activated by an overstimulated EGFR pathway. METHODS: This phase I dose escalation trial assessed the safety and efficacy of vinflun...

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Autores principales: Sanoff, Hanna K., Davies, Janine M., Walko, Christine, Irvin, William, Buie, Larry, Keller, Kimberly, Ivanova, Anastasia, Chiu, Wing-Keung, O'Neil, Bert H., Stinchcombe, Thomas E., Dees, E. Claire
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2988886/
https://ncbi.nlm.nih.gov/pubmed/20387090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-010-9427-1
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